Molecular and synaptic defects in intellectual disability syndromes

@article{Verpelli2012MolecularAS,
  title={Molecular and synaptic defects in intellectual disability syndromes},
  author={Chiara Verpelli and Carlo Sala},
  journal={Current Opinion in Neurobiology},
  year={2012},
  volume={22},
  pages={530-536}
}
The search for genetic causes of intellectual disability has identified, over the past twenty years, numerous mutated genes that code for proteins concerned with synapse function. Functional studies have shown that these genes may be involved in synapse formation, the synthesis and degradation of specific synapse proteins, the regulation of dendritic spine morphology, or regulation of the synaptic cytoskeleton. It is now clear that even mild alterations in synapse morphology and function can… CONTINUE READING
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