Molecular and structural characterization of the PezAT chromosomal toxin-antitoxin system of the human pathogen Streptococcus pneumoniae.

@article{Khoo2007MolecularAS,
  title={Molecular and structural characterization of the PezAT chromosomal toxin-antitoxin system of the human pathogen Streptococcus pneumoniae.},
  author={Seok Kooi Khoo and Bernhard Loll and Wai Ting Chan and Robert Laturner Shoeman and Lena Ngoo and Chew Chieng Yeo and Anton Meinhart},
  journal={The Journal of biological chemistry},
  year={2007},
  volume={282 27},
  pages={
          19606-18
        }
}
The chromosomal pezT gene of the Gram-positive pathogen Streptococcus pneumoniae encodes a protein that is homologous to the zeta toxin of the Streptococcus pyogenes plasmid pSM19035-encoded epsilon-zeta toxin-antitoxin system. Overexpression of pezT in Escherichia coli led to severe growth inhibition from which the bacteria recovered approximately 3 h after induction of expression. The toxicity of PezT was counteracted by PezA, which is encoded immediately upstream of pezT and shares weak… CONTINUE READING

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