Molecular and structural biology of bleomycin and its resistance determinants.

@article{Sugiyama2002MolecularAS,
  title={Molecular and structural biology of bleomycin and its resistance determinants.},
  author={Masanori Sugiyama and Takanori Kumagai},
  journal={Journal of bioscience and bioengineering},
  year={2002},
  volume={93 2},
  pages={105-16}
}
An anti-tumor antibiotic, bleomycin (Bm), causes cell death as a result of multiple strand scissions by direct interaction with bacterial and tumor cell DNAs. Some prokaryotic and eukaryotic cells have a system to protect themselves from Bm-induced toxicity. In eukaryotes, the response of normal and tumor cells to toxicity depends on the level of Bm hydrolase activity. The inactivation system of Bm, which hydrolyzes the amide in the beta-aminoalanine moiety of Bm, is also found in a few… CONTINUE READING