Molecular and structural basis for redox regulation of beta-actin.

  title={Molecular and structural basis for redox regulation of beta-actin.},
  author={Ingrid Lassing and Florian Schmitzberger and Mikael Bj{\"o}rnstedt and Arne Holmgren and Paer Nordlund and Clarence Schutt and Uno Lindberg},
  journal={Journal of molecular biology},
  volume={370 2},
An essential consequence of growth factor-mediated signal transduction is the generation of intracellular H(2)O(2). It operates as a second messenger in the control of actin microfilament dynamics, causing rapid and dramatic changes in the morphology and motile activity of stimulated cells. Little is understood about the molecular mechanisms causing these changes in the actin system. Here, it is shown that H(2)O(2) acts directly upon several levels of this system, and some of the mechanistic… CONTINUE READING

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