Molecular and structural analysis of mosaic variants of penicillin-binding protein 2 conferring decreased susceptibility to expanded-spectrum cephalosporins in Neisseria gonorrhoeae: role of epistatic mutations.

@article{Tomberg2010MolecularAS,
  title={Molecular and structural analysis of mosaic variants of penicillin-binding protein 2 conferring decreased susceptibility to expanded-spectrum cephalosporins in Neisseria gonorrhoeae: role of epistatic mutations.},
  author={Joshua Tomberg and Magnus Unemo and Christopher Davies and Robert A Nicholas},
  journal={Biochemistry},
  year={2010},
  volume={49 37},
  pages={8062-70}
}
Mutations in penicillin-binding protein 2 (PBP 2) encoded by mosaic penA alleles are crucial for intermediate resistance to the expanded-spectrum cephalosporins ceftriaxone and cefixime in Neisseria gonorrhoeae. Three of the ∼60 mutations present in mosaic alleles of penA, G545S, I312M, and V316T, have been reported to be responsible for increased resistance, especially to cefixime [Takahata, S., et al. (2006) Antimicrob. Agents Chemother. 50, 3638-3645]. However, we observed that the minimum… CONTINUE READING
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Molecular Mechanisms of Antibiotic Resistance Expressed by the Pathogenic Neisseria

  • W. M. Shafer, J. P. Folster, R. A. Nicholas
  • In Neisseria: Molecular Mechanisms of…
  • 2010

by overlap extension using the polymerase chain reaction

  • A. J. Powell, J. Tomberg, A. M. Deacon, R. A. Nicholas, C. Davies
  • 2009

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