Molecular and physiological characterization of RV remodeling in a murine model of pulmonary stenosis.

@article{Urashima2008MolecularAP,
  title={Molecular and physiological characterization of RV remodeling in a murine model of pulmonary stenosis.},
  author={Takashi Urashima and Mingming Zhao and Roger Wagner and Giovanni Fajardo and Sara Jalali Farahani and Tom Quertermous and D. Bernstein},
  journal={American journal of physiology. Heart and circulatory physiology},
  year={2008},
  volume={295 3},
  pages={
          H1351-H1368
        }
}
Right ventricular (RV) dysfunction is a common long-term complication in patients after the repair of congenital heart disease. Previous investigators have examined the cellular and molecular mechanisms of left ventricular (LV) remodeling, but little is known about the stressed RV. Our purpose was to provide a detailed physiological characterization of a model of RV hypertrophy and failure, including RV-LV interaction, and to compare gene alterations between afterloaded RV versus LV. Pulmonary… CONTINUE READING
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