Molecular and phylogenetic analysis of the HPV 16 E4 gene in cervical lesions from women in Greece

@article{Tsakogiannis2012MolecularAP,
  title={Molecular and phylogenetic analysis of the HPV 16 E4 gene in cervical lesions from women in Greece},
  author={Dimitris Tsakogiannis and Irina Georgia Anna Ruether and Zaharoula Kyriakopoulou and Vaia Pliaka and Vaios Skordas and Constantina Gartzonika and Stamatina Levidiotou-Stefanou and Panayotis Markoulatos},
  journal={Archives of Virology},
  year={2012},
  volume={157},
  pages={1729-1739}
}
The HPV16 E1∧E4 protein is thought to contribute to the release of newly formed viral particles from infected epithelia. In order to investigate amino acid mutations in the HPV16 E1∧E4 protein, the complete E4 ORF was amplified by PCR in 27 HPV16-positive cervical samples, and the amplicons were cloned. Fifteen nucleic acid variations were identified in the E4 ORF, including seven silent nucleic acid mutations. In addition, nine amino acid mutations (A7V, A7P, L16I, D45E, L59I, L59T, Q66P, S72F… CONTINUE READING
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