Molecular and phenotypic analysis of Philadelphia chromosome-positive bilineage leukemia: possibility of a lineage switch from T-lymphoid leukemic progenitor to myeloid cells.

@article{Monma2006MolecularAP,
  title={Molecular and phenotypic analysis of Philadelphia chromosome-positive bilineage leukemia: possibility of a lineage switch from T-lymphoid leukemic progenitor to myeloid cells.},
  author={Fumihiko Monma and Kazuhiro Nishii and Shiho Ezuki and Toshiyasu Miyazaki and S. Yamamori and Eiji Usui and Yuka Sugimoto and V FelipeLorenzo and Naoyuki Katayama and Hiroshi Shiku},
  journal={Cancer genetics and cytogenetics},
  year={2006},
  volume={164 2},
  pages={118-21}
}
The occurrence of acute bilineage leukemia is thought to be the malignant transformation of a myeloid or lymphoid leukemic progenitor with the potential to differentiate into the other lineages; however, the mechanisms of this lineage switch are not well understood. Here, we report on the extremely rare case of adult Philadelphia chromosome-positive acute bilineage leukemia, which is characterized by T-cell acute lymphoblastic leukemia and acute myelomonocytic leukemia. Chromosome analysis… CONTINUE READING

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