Molecular and pharmacological characterization of GABA(A) receptor alpha1 subunit knockout mice.

@article{Kralic2002MolecularAP,
  title={Molecular and pharmacological characterization of GABA(A) receptor alpha1 subunit knockout mice.},
  author={Jason E. Kralic and Esa R Korpi and Todd K O'Buckley and Gregg E Homanics and A Leslie Morrow},
  journal={The Journal of pharmacology and experimental therapeutics},
  year={2002},
  volume={302 3},
  pages={
          1037-45
        }
}
GABA(A) receptors mediate fast inhibitory neurotransmission in the central nervous system (CNS), and approximately half of these receptors contain alpha1 subunits. GABA(A) receptor alpha1 subunits are important for receptor assembly and specific pharmacological responses to benzodiazepines. Plasticity in GABA(A) receptor alpha1 subunit expression is associated with changes in CNS excitability observed during normal brain development, in animal models of epilepsy, and upon withdrawal from… CONTINUE READING

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