Molecular and pharmacological blockade of the EP4 receptor selectively inhibits both proliferation and invasion of human inflammatory breast cancer cells.

@article{Robertson2008MolecularAP,
  title={Molecular and pharmacological blockade of the EP4 receptor selectively inhibits both proliferation and invasion of human inflammatory breast cancer cells.},
  author={Fredika M. Robertson and A Simeone and Abhijit Mazumdar and Ashish Harish Shah and John S. McMurray and Sukhen C. Ghosh and Massimo Cristofanilli},
  journal={Journal of experimental therapeutics & oncology},
  year={2008},
  volume={7 4},
  pages={299-312}
}
Inflammatory breast cancer (IBC) is the most aggressive form of locally advanced breast cancer (LABC) characterized by rapid growth and aggressive invasion with no selective therapies developed to treat IBC. Cyclooxygenase-2 (Cox-2), which produces prostaglandin E2 (PGE2) is known to be upregulated in primary IBC tumors and metastatic lesions, however the use of selective Cox-2 inhibitors has diminished due to cardiovascular side effects. One alternative approach to targeting Cox-2 enzyme… CONTINUE READING

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