Molecular and pathological signatures of epithelial–mesenchymal transitions at the cancer invasion front

@article{Wever2008MolecularAP,
  title={Molecular and pathological signatures of epithelial–mesenchymal transitions at the cancer invasion front},
  author={Olivier De Wever and Patrick Pauwels and Bram De Craene and Mich{\`e}le Sabbah and Shahin Emami and G{\'e}rard Redeuilh and Christian P Gespach and Marc E. Bracke and Geert Berx},
  journal={Histochemistry and Cell Biology},
  year={2008},
  volume={130},
  pages={481 - 494}
}
Reduction of epithelial cell–cell adhesion via the transcriptional repression of cadherins in combination with the acquisition of mesenchymal properties are key determinants of epithelial–mesenchymal transition (EMT). EMT is associated with early stages of carcinogenesis, cancer invasion and recurrence. Furthermore, the tumor stroma dictates EMT through intensive bidirectional communication. The pathological analysis of EMT signatures is critically, especially to determine the presence of… CONTINUE READING

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