Molecular and neuronal substrate for the selective attenuation of anxiety.

@article{Loew2000MolecularAN,
  title={Molecular and neuronal substrate for the selective attenuation of anxiety.},
  author={K. M. Loew and Florence Crestani and Ruth Keist and Dietmar Benke and Ina Br{\"u}nig and Jack A. Benson and Jean-Marc Fritschy and Thomas R{\"u}licke and Horst Bluethmann and Hanns M{\"o}hler and Uwe Rudolph},
  journal={Science},
  year={2000},
  volume={290 5489},
  pages={131-4}
}
Benzodiazepine tranquilizers are used in the treatment of anxiety disorders. To identify the molecular and neuronal target mediating the anxiolytic action of benzodiazepines, we generated and analyzed two mouse lines in which the alpha2 or alpha3 GABAA (gamma-aminobutyric acid type A) receptors, respectively, were rendered insensitive to diazepam by a knock-in point mutation. The anxiolytic action of diazepam was absent in mice with the alpha2(H101R) point mutation but present in mice with the… CONTINUE READING
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