Molecular and metabolic changes in white adipose tissue of the rat during development of ventromedial hypothalamic obesity.

@article{Cousin1992MolecularAM,
  title={Molecular and metabolic changes in white adipose tissue of the rat during development of ventromedial hypothalamic obesity.},
  author={Beatrice Cousin and Kenji Agou and Armelle Leturque and Pascal Ferr{\'e} and Jean Girard and Luc P{\'e}nicaud},
  journal={European journal of biochemistry},
  year={1992},
  volume={207 1},
  pages={377-82}
}
We have previously shown that rats made obese by lesion of ventromedial hypothalamus (VMH) nuclei, demonstrate an hyper-responsiveness to insulin with regard to whole-body glucose utilization one week after injury. This is mainly due to an increased glucose uptake in white adipose tissue. Six weeks after the lesion, glucose utilization in white adipose… CONTINUE READING