Molecular and mesoscale mechanisms of osteogenesis imperfecta disease in collagen fibrils.

@article{Gautieri2009MolecularAM,
  title={Molecular and mesoscale mechanisms of osteogenesis imperfecta disease in collagen fibrils.},
  author={Alfonso Gautieri and Sebastien G M Uzel and Simone Vesentini and Alberto Redaelli and Markus J Buehler},
  journal={Biophysical journal},
  year={2009},
  volume={97 3},
  pages={857-65}
}
Osteogenesis imperfecta (OI) is a genetic disorder in collagen characterized by mechanically weakened tendon, fragile bones, skeletal deformities, and in severe cases, prenatal death. Although many studies have attempted to associate specific mutation types with phenotypic severity, the molecular and mesoscale mechanisms by which a single point mutation influences the mechanical behavior of tissues at multiple length scales remain unknown. We show by a hierarchy of full atomistic and mesoscale… CONTINUE READING