Molecular and mechanical synergy: cross-talk between integrins and growth factor receptors.

@article{Ross2004MolecularAM,
  title={Molecular and mechanical synergy: cross-talk between integrins and growth factor receptors.},
  author={Robert S Ross},
  journal={Cardiovascular research},
  year={2004},
  volume={63 3},
  pages={381-90}
}
The full repertoire of molecules and mechanisms which lead to cardiac hypertrophy are poorly understood. Many studies over the last several decades have shown how various growth factors are involved in the hypertrophic response. It has also been intuitively obvious that mechanical mechanisms which impose hemodynamic loads on the working myocardium must also be involved in this process. Integrins are cell adhesion receptors that are potent bi-directional signaling molecules. They are cellular… CONTINUE READING
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