Molecular and integrative physiology of intestinal peptide transport.

  title={Molecular and integrative physiology of intestinal peptide transport.},
  author={Hannelore Daniel},
  journal={Annual review of physiology},
Intestinal protein digestion generates a huge variety and quantity of short chain peptides that are absorbed into intestinal epithelial cells by the PEPT1 transporter in the apical membrane of enterocytes. PEPT1 operates as an electrogenic proton/peptide symporter with the ability to transport essentially every possible di- and tripeptide. Transport is enantio-selective and involves a variable proton-to-substrate stoichiometry for uptake of neutral and mono- or polyvalently charged peptides… CONTINUE READING
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