Molecular and hematological characterization of hemoglobin Hope/hemoglobin E and hemoglobin Hope/alpha-thalassemia 2 in Thai patients.

@article{Chunpanich2004MolecularAH,
  title={Molecular and hematological characterization of hemoglobin Hope/hemoglobin E and hemoglobin Hope/alpha-thalassemia 2 in Thai patients.},
  author={Sunisa Chunpanich and Supan Fucharoen and Kanokwan Sanchaisuriya and Goonnapa Fucharoen and Kasian Kam-itsara},
  journal={Laboratory hematology : official publication of the International Society for Laboratory Hematology},
  year={2004},
  volume={10 4},
  pages={
          215-20
        }
}
We report the hematological and molecular characterization of compound heterozygosity for hemoglobin (Hb) Hope/Hb E and double heterozygosity for Hb Hope/ alpha-thalassemia 2 found in 2 unrelated Thai individuals. The first proband presented with slight anemia and mild hypochromic microcytosis. Routine cellulose acetate Hb electrophoresis at pH 8.6 revealed in addition to Hb E another variant migrating slightly more anodic to Hb A. On cation exchange high-pressure liquid chromatography, the… CONTINUE READING
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