Molecular and genotypic characterization of human thyroid follicular cell carcinoma-derived cell lines.

@article{Meireles2007MolecularAG,
  title={Molecular and genotypic characterization of human thyroid follicular cell carcinoma-derived cell lines.},
  author={Ana Margarida Meireles and Artur de Lima Preto and Ana Sofia Rocha and Ana Paula Rebocho and Valdemar M{\'a}ximo and Isabel Pereira-Castro and Severina Moreira and T{\'a}lia Feij{\~a}o and Tarc{\'i}sio R. Botelho and Ricardo Marques and Vitor Trovisco and Lu{\'i}s Cirnes and C{\'i}ntia Fontes Alves and S{\'e}rgia Velho and Paula Soares and Manuel Sobrinho-Sim{\~o}es},
  journal={Thyroid : official journal of the American Thyroid Association},
  year={2007},
  volume={17 8},
  pages={
          707-15
        }
}
OBJECTIVE Our aim was to characterize the molecular and genotypic profile of eight thyroid carcinoma-derived cell lines-TPC1, FB2, B-CPAP, K1, XTC-1, C643, 8505C, and Hth74-in order to use them as in vitro models of thyroid carcinogenesis. DESIGN We evaluated the expression of five thyroid-specific genes (Tg, TSHr, TPO, PAX8, and TTF-1) to establish the cell lineage and to assess the differentiation status of each of the cell lines. We screened for mutations in the most relevant oncogenes… CONTINUE READING
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