Molecular and genetic characterization of a radiation-induced structural rearrangement in mouse chromosome 2 causing mutations at the limb deformity and agouti loci.

@article{Woychik1990MolecularAG,
  title={Molecular and genetic characterization of a radiation-induced structural rearrangement in mouse chromosome 2 causing mutations at the limb deformity and agouti loci.},
  author={Richard P. Woychik and Walderico M. Generoso and Liane Brauch Russell and Ken Cain and Nestor L. A. Cacheiro and Scott J. Bultman and Paul Bruce Selby and Mark Everett Dickinson and Brigid L. M. Hogan and Joe C. Rutledge},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1990},
  volume={87 7},
  pages={
          2588-92
        }
}
Molecular characterization of mutations in the mouse, particularly those involving agent-induced major structural alterations, is proving to be useful for correlating the structure and expression of individual genes with their function in the whole organism. Here we present the characterization of a radiation-induced mutation that simultaneously generated distinct alleles of both the limb deformity (ld) and agouti (a) loci, two developmentally important regions of chromosome 2 normally… CONTINUE READING
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