Molecular and functional resemblance of differentiated cells derived from isogenic human iPSCs and SCNT-derived ESCs.

@article{Zhao2017MolecularAF,
  title={Molecular and functional resemblance of differentiated cells derived from isogenic human iPSCs and SCNT-derived ESCs.},
  author={Ming-Tao Zhao and Haodong Chen and Qing Liu and Ning-Yi Shao and Nazish Sayed and Hung-Ta Wo and Joe Z. Zhang and Sang-Ging Ong and Chun Liu and Youngkyun Kim and Huaxiao Yang and Tony Chour and Hong Ma and Nuria Marti Gutierrez and Ioannis Karakikes and Shoukhrat Mitalipov and Michael P. Snyder and Joseph C Wu},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2017},
  volume={114 52},
  pages={
          E11111-E11120
        }
}
Patient-specific pluripotent stem cells (PSCs) can be generated via nuclear reprogramming by transcription factors (i.e., induced pluripotent stem cells, iPSCs) or by somatic cell nuclear transfer (SCNT). However, abnormalities and preclinical application of differentiated cells generated by different reprogramming mechanisms have yet to be evaluated. Here we investigated the molecular and functional features, and drug response of cardiomyocytes (PSC-CMs) and endothelial cells (PSC-ECs) derived… CONTINUE READING
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Cell type-specific chromatin signatures underline regulatory DNA elements in human induced pluripotent stem cells and somatic cells

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