Molecular and functional properties of two-pore-domain potassium channels.

@article{Lesage2000MolecularAF,
  title={Molecular and functional properties of two-pore-domain potassium channels.},
  author={Florian Lesage and Michel Lazdunski},
  journal={American journal of physiology. Renal physiology},
  year={2000},
  volume={279 5},
  pages={
          F793-801
        }
}
  • Florian Lesage, Michel Lazdunski
  • Published 2000
  • Medicine, Chemistry
  • American journal of physiology. Renal physiology
  • The two-pore-domain K(+) channels, or K(2P) channels, constitute a novel class of K(+) channel subunits. They have four transmembrane segments and are active as dimers. The tissue distribution of these channels is widespread, and they are found in both excitable and nonexcitable cells. K(2P) channels produce currents with unusual characteristics. They are quasi-instantaneous and noninactivating, and they are active at all membrane potentials and insensitive to the classic K(+) channel blockers… CONTINUE READING

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