Molecular and functional interdependence of the urokinase-type plasminogen activator system with integrins.

@article{Reuning2003MolecularAF,
  title={Molecular and functional interdependence of the urokinase-type plasminogen activator system with integrins.},
  author={Ute Reuning and Viktor Magdolen and Sandra Hapke and Manfred Schmitt},
  journal={Biological chemistry},
  year={2003},
  volume={384 8},
  pages={1119-31}
}
The serine protease urokinase-type plasminogen activator (uPA), its inhibitor PAI-1, and its cellular receptor uPA-R (CD87) are of crucial importance during cellular invasion and migration, required for a variety of physio- and pathophysiological processes. It has become increasingly evident in recent years that the uPA/uPA-R-system has far more functional properties than plasminogen activation alone. This is reflected by its involvement in cellular events such as proliferation, adhesion… CONTINUE READING

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