Molecular and functional diversity of the expanding GABA-A receptor gene family.

  title={Molecular and functional diversity of the expanding GABA-A receptor gene family.},
  author={Paul John Whiting and Timothy P. Bonnert and Ruth M Mckernan and S C Farrar and B{\'e}atrice Le Bourdell{\`e}s and Robert P. Heavens and David W Smith and Louise Hewson and M R Rigby and Dalip J. S. Sirinathsinghji and Sally Ann Thompson and Keith A Wafford},
  journal={Annals of the New York Academy of Sciences},
Fast inhibitory neurotransmission in the mammalian CNS is mediated primarily by the neurotransmitter gamma-aminobutyric acid (GABA), which, upon binding to its receptor, leads to opening of the intrinsic ion channel, allowing chloride to enter the cell. Over the past 10 years it has become clear that a family of GABA-A receptor subtypes exists, generated through the coassembly of polypeptides selected from alpha 1-alpha 6, beta 1-beta 3, gamma 1-gamma 3, delta, epsilon, and pie to form what is… CONTINUE READING


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