Molecular and functional characterization of the small Ca2+-regulated K+ channel (rSK4) of colonic crypts

Colonic crypt cells possess basolateral Ca2+-regulated K+ channels which support Cl– secretion by providing the necessary driving force. The pharmacological characteristics of these channels were examined in Ussing chamber experiments of rat and rabbit colon mucosa by the use of blockers. The chromanol 293B, a blocker of KVLQT1 channels, and clotrimazole… (More)