Molecular and functional characterization of acid-sensing ion channel (ASIC) 1b.

  title={Molecular and functional characterization of acid-sensing ion channel (ASIC) 1b.},
  author={Elke Baessler and Thu Jennifer Ngo-Anh and H S Geisler and Johann Peter Ruppersberg and Stefan Gr{\"u}nder},
  journal={The Journal of biological chemistry},
  volume={276 36},
Acid-sensing ion channels (ASICs) are activated by extracellular protons and are involved in neurotransmission in the central nervous system, in pain perception, as well as in mechanotransduction. Six different ASIC subunits have been cloned to date, which are encoded by four genes (ASIC1-ASIC4). Proton-gated currents have been described in isolated neurons from sensory ganglia as well as from central nervous system. However, it is largely unclear which of the cloned ASIC subunits underlie… CONTINUE READING
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