Molecular and functional characterization of inwardly rectifying K+ currents in murine proximal colon.

@article{Huang2018MolecularAF,
  title={Molecular and functional characterization of inwardly rectifying K+ currents in murine proximal colon.},
  author={Xu Huang and Si Hyung Lee and Hongli Lu and Kenton M. Sanders and Sang Don Koh},
  journal={The Journal of physiology},
  year={2018},
  volume={596 3},
  pages={
          379-391
        }
}
KEY POINTS Interstitial cells of Cajal (ICC) from murine colonic muscles express genes encoding inwardly rectifying K+ channels. Transcripts of Kcnj2 (Kir2.1), Kcnj4 (Kir2.3), Kcnj14 (Kir2.4), Kcnj5 (Kir3.4), Kcnj8 (Kir 6.1) and Kcnj11 (Kir6.2) were found in colonic ICC. A conductance with properties consistent with Kir2 channels was observed in ICC but not in smooth muscle cells (SMC). Despite expression of gene transcripts, G-protein gated K+ channel (Kir3) and KATP (Kir6) currents were not… CONTINUE READING

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