Molecular and functional characteristics of the Fcα/μR, a novel Fc receptor for IgM and IgA

@article{Shibuya2006MolecularAF,
  title={Molecular and functional characteristics of the Fc$\alpha$/$\mu$R, a novel Fc receptor for IgM and IgA},
  author={Akira Shibuya and Shin‐ichiro Honda},
  journal={Springer Seminars in Immunopathology},
  year={2006},
  volume={28},
  pages={377-382}
}
  • A. Shibuya, S. Honda
  • Published 24 October 2006
  • Biology, Medicine
  • Springer Seminars in Immunopathology
IgM is the first antibody to be produced in a humoral immune response and is a major isotope of natural antibodies and may play an important role in innate immunity. On the other hand, IgA is a secreted antibody at the mucosal membrane such as the gastrointestinal and respiratory tracts and protects from initial invasion of microbes. However, how these antibodies are involved in immunity has been poorly elucidated. We previously identified a novel Fc receptor for IgA and IgM, designated Fc… 
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Fcα/μR is a unique Fc receptor that is involved in humoral immune responses and inflammation.
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The role of FcμR in B cell development, maturation, survival and activation, antibody production, host defense against bacterial and viral infections, and B cell tolerance is reviewed.
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The molecular and functional characteristics of Fc α/μR in comparison with poly-IgR, FcμR and FcαRI are summarized, and particularly on the pro-inflammatory function of F cα/ μR expressed on marginal zone B cells in sepsis are focused on.
Immunoglobulin–Fc Receptor Interactions
The chicken leukocyte receptor complex encodes a primordial, activating, high-affinity IgY Fc receptor
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A nonmammalian Fcγ receptor, CHIR-AB1, a member of the leukocyte receptor complex, that binds IgY with high affinity with its single Ig domain is described, representing a primordial Fc receptor that combines features of different mammalian counterparts.
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The discovery of new Fc-receptors for IgM requires revision of notions that interactions between humoral reactions involving IgM and the cells of the immune system are mediated exclusively by complement receptors.
Cytoplasmic domain of human Fcalpha/mu receptor is required for ligand internalization.
Identification of the Fcalpha/muR isoform specifically expressed in the kidney tubules.
Requirement of the cytoplasmic portion for dimer formation of Fcalpha/micro receptor expressed on cell surface.
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TLDR
It is shown that the Fcα/μ receptor is expressed on mature, but not immature, B lymphocytes and acquires the ability to bind IgM and IgA antibodies after stimulation of B lymphocyte after stimulation with phorbol 12‐myristate 13‐acetate.
Molecular characteristics of IgA and IgM Fc binding to the Fcα/μR
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TLDR
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TLDR
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