Molecular and functional characteristics of the Fcα/μR, a novel Fc receptor for IgM and IgA

@article{Shibuya2006MolecularAF,
  title={Molecular and functional characteristics of the Fc$\alpha$/$\mu$R, a novel Fc receptor for IgM and IgA},
  author={Akira Shibuya and Shin‐ichiro Honda},
  journal={Springer Seminars in Immunopathology},
  year={2006},
  volume={28},
  pages={377-382}
}
  • A. Shibuya, S. Honda
  • Published 24 October 2006
  • Biology, Medicine
  • Springer Seminars in Immunopathology
IgM is the first antibody to be produced in a humoral immune response and is a major isotope of natural antibodies and may play an important role in innate immunity. On the other hand, IgA is a secreted antibody at the mucosal membrane such as the gastrointestinal and respiratory tracts and protects from initial invasion of microbes. However, how these antibodies are involved in immunity has been poorly elucidated. We previously identified a novel Fc receptor for IgA and IgM, designated Fc… 
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TLDR
It is shown that the Fcα/μ receptor is expressed on mature, but not immature, B lymphocytes and acquires the ability to bind IgM and IgA antibodies after stimulation of B lymphocyte after stimulation with phorbol 12‐myristate 13‐acetate.
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It is suggested that IgA and IgM bind to an epitope in the conserved amino acids in the Ig-like domain of Fcalpha/muR as well as poly-IgR, a type I transmembrane protein with an immunoglobulin (Ig)-like domain in the extracellular portion.
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TLDR
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TLDR
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TLDR
It is shown that primary HMCs express mRNA for a novel receptor, the Fc alpha/mu receptor (Fcα/μR), and that receptor expression is upregulated by IL-1, and that Fcα-μR may be the receptor responsible for mesangial IgA deposition in IgA nephropathy.
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