Molecular and functional characteristics of APJ. Tissue distribution of mRNA and interaction with the endogenous ligand apelin.

@article{Hosoya2000MolecularAF,
  title={Molecular and functional characteristics of APJ. Tissue distribution of mRNA and interaction with the endogenous ligand apelin.},
  author={Masaki Hosoya and Yuji Kawamata and Shoji Fukusumi and Ryo Fujii and Yugo Habata and Shuji Hinuma and Chieko Kitada and Shinya Honda and Tomofumi Kurokawa and Haruo Onda and Osamu Nishimura and Masahiko Fujino},
  journal={The Journal of biological chemistry},
  year={2000},
  volume={275 28},
  pages={21061-7}
}
We have recently identified apelin as the endogenous ligand for human APJ. In rats, the highest expression of APJ mRNA was detected in the lung, suggesting that APJ and its ligand play an important role in the pulmonary system. When apelin-36 and its pyroglutamylated C-terminal peptide, [<Glu(65)]apelin-13, were compared in microphysiometric analyses, the elevation of extracellular acidification induced in cells expressing APJ by [<Glu(65)]apelin-13 was transient, whereas that by apelin-36 was… CONTINUE READING
Highly Influential
This paper has highly influenced 12 other papers. REVIEW HIGHLY INFLUENTIAL CITATIONS

Citations

Publications citing this paper.
Showing 1-10 of 152 extracted citations

Similar Papers

Loading similar papers…