Molecular and functional analysis of SDCT2, a novel rat sodium-dependent dicarboxylate transporter.

@article{Chen1999MolecularAF,
  title={Molecular and functional analysis of SDCT2, a novel rat sodium-dependent dicarboxylate transporter.},
  author={Xinhua Chen and Hiroyasu Tsukaguchi and Xing Chen and Urs V. Berger and M. A. Hediger},
  journal={The Journal of clinical investigation},
  year={1999},
  volume={103 8},
  pages={
          1159-68
        }
}
Kidney proximal tubule cells take up Krebs cycle intermediates for metabolic purposes and for secretion of organic anions through dicarboxylate/organic anion exchange. Alteration in reabsorption of citrate is closely related to renal stone formation. The presence of distinct types of sodium-coupled dicarboxylate transporters has been postulated on either side of the polarized epithelial membrane in the kidney proximal tubule. Using a PCR-based approach, we isolated a novel member of the sodium… Expand
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Organic anions are taken up from the blood into proximal tubule cells by organic anion transporters 1 and 3 (OAT1 and OAT3) in exchange for dicarboxylates. The released dicarboxylates are recycled byExpand
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