Molecular and functional analyses of the human and mouse genes encoding AFG3L1, a mitochondrial metalloprotease homologous to the human spastic paraplegia protein.

@article{Kremmidiotis2001MolecularAF,
  title={Molecular and functional analyses of the human and mouse genes encoding AFG3L1, a mitochondrial metalloprotease homologous to the human spastic paraplegia protein.},
  author={Gabriel Kremmidiotis and Alison E. Gardner and Chatri Settasatian and Anna Savoia and Grant R. Sutherland and David Frederick Callen},
  journal={Genomics},
  year={2001},
  volume={76 1-3},
  pages={58-65}
}
The identification of SPG7 as the gene defective in a recessive form of spastic paraplegia has drawn attention to the yeast protein family of ATP-dependent zinc metalloproteases. The protein encoded by SPG7, paraplegin, shows high homology to members of this protein family. Recently, many mammalian ATP-dependent zinc metalloproteases have been identified and considered as possible candidates for defects in other forms of hereditary spastic paraplegia and possibly other neurodegenerative… CONTINUE READING

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