Molecular and electrophysiological differences in the L-type Ca2+ channel of the atrium and ventricle of rat hearts.

@article{Hatano2006MolecularAE,
  title={Molecular and electrophysiological differences in the L-type Ca2+ channel of the atrium and ventricle of rat hearts.},
  author={Seiji Hatano and Takeshi Yamashita and Akiko Sekiguchi and Yuki Iwasaki and Kiyoshi Nakazawa and Koichi Sagara and Hiroyuki Iinuma and Tadanori Aizawa and L Fu},
  journal={Circulation journal : official journal of the Japanese Circulation Society},
  year={2006},
  volume={70 5},
  pages={610-4}
}
BACKGROUND Many pathological conditions induce electrical remodeling, possibly through intracellular Ca2+ overload, but the currently available L-type Ca2+ channel blockers may be detrimental because of their global negative inotropic effects. METHODS AND RESULTS To determine whether the L-type Ca2+ channel is identical throughout the heart, the distribution of the mRNAs and proteins comprising the L-type Ca2+ channel and its electrophysiological properties were analyzed in rat atria and… CONTINUE READING