Molecular and electrophysiological characterization of transient receptor potential ion channels in the primary murine megakaryocyte.

@article{Carter2006MolecularAE,
  title={Molecular and electrophysiological characterization of transient receptor potential ion channels in the primary murine megakaryocyte.},
  author={Richard N. Carter and Gwen Tolhurst and Gemma L. Walmsley and Matthieu Vizuete-Forster and Nigel Miller and Martyn P. Mahaut-Smith},
  journal={The Journal of physiology},
  year={2006},
  volume={576 Pt 1},
  pages={151-62}
}
The molecular identity of platelet Ca(2+) entry pathways is controversial. Furthermore, the extent to which Ca(2+)-permeable ion channels are functional in these tiny, anucleate cells is difficult to assess by direct electrophysiological measurements. Recent work has highlighted how the primary megakaryocyte represents a bona fide surrogate for studies of platelet signalling, including patch clamp recordings of ionic conductances. We have now screened for all known members of the transient… CONTINUE READING
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