Molecular and developmental analyses of thyroid hormone receptor function in Xenopus laevis, the African clawed frog.

@article{Buchholz2006MolecularAD,
  title={Molecular and developmental analyses of thyroid hormone receptor function in Xenopus laevis, the African clawed frog.},
  author={Daniel R. Buchholz and Bindu D Paul and Liezhen Fu and Yunbo Shi},
  journal={General and comparative endocrinology},
  year={2006},
  volume={145 1},
  pages={1-19}
}
The current review focuses on the molecular mechanisms and developmental roles of thyroid hormone receptors (TRs) in gene regulation and metamorphosis in Xenopus laevis and discusses implications for TR function in vertebrate development and diversity. Questions addressed are: (1) what are the molecular mechanisms of gene regulation by TR, (2) what are the developmental roles of TR in mediating the thyroid hormone (TH) signal, (3) what are the roles of the different TR isoforms, and (4) how do… CONTINUE READING