Molecular and clinicopathologic characterization of gastrointestinal stromal tumors (GISTs) of small size.

  title={Molecular and clinicopathologic characterization of gastrointestinal stromal tumors (GISTs) of small size.},
  author={Sabrina Rossi and Daniela Gasparotto and Luisa Toffolatti and Chiara Pastrello and Giovanna Gallina and Alessandra Marzotto and Chiara Sartor and Mattia Barbareschi and Chiara Cantaloni and Luca Messerini and Italo Bearzi and Giannantonio Arrigoni and Guido Mazzoleni and Jonathan Alfred Fletcher and Paolo Giovanni Casali and Renato Talamini and Roberta Maestro and Angelo P Dei Tos},
  journal={The American journal of surgical pathology},
  volume={34 10},
Although Gastrointestinal stromal tumors (GISTs) affect about 0.0014% of the population, GISTs smaller than 1 cm (microGISTs) are detectable in about 20% to 30% of elderly individuals. This suggests that microGISTs likely represent premalignant precursors that evolve only in a minute fraction of cases toward overt GISTs. We sought histopathologic and molecular explanations for the infrequent clinical progression in small GISTs. To investigate the mechanisms of GIST progression and identify… CONTINUE READING


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