Molecular and clinical characteristics of hepatitis B virus in Korea.

  title={Molecular and clinical characteristics of hepatitis B virus in Korea.},
  author={Sang Hoon Ahn and Lilly Yuen and Kwang-hyub Han and Margaret Littlejohn and Hye Young Chang and Hans C Damerow and Anna Ayres and Jeong Heo and Stephen L. Locarnini and Peter A. Revill},
  journal={Journal of medical virology},
  volume={82 7},
Korea is an endemic area of hepatitis B virus (HBV) infection but very little is known about the molecular characteristics of HBV isolates from Korean patients or the association with disease progression. The complete HBV genome sequences from 53 Korean patients with chronic hepatitis B, advanced cirrhosis, or hepatocellular carcinoma (HCC) were analyzed to identify (i) subgenotype distribution and genetic diversity and (ii) signature mutations associated with liver disease progression. With… CONTINUE READING