Molecular and chromosomal mutations among children with B-lineage lymphoblastic leukemia in Brazil's Federal District.

  title={Molecular and chromosomal mutations among children with B-lineage lymphoblastic leukemia in Brazil's Federal District.},
  author={Debora Rodrigues Mesquita and Jose Carlos C{\'o}rdoba and Isis Quezado Magalh{\~a}es and Mara Santos C{\'o}rdoba and Jo{\~a}o Ricardhis S. Oliveira and Anthony Gonçalv{\`e}s and Iris Ferrari and Cezar Martins-de-S{\'a}},
  journal={Genetics and molecular research : GMR},
  volume={8 1},
Acute lymphoblastic leukemia (ALL) accounts for approximately 80% of all acute leukemias during childhood. Chromosomal anomalies resulting from gene fusion, which are frequent in leukemias, create hybrid transcripts, the great majority of which encode transcription factors. We analyzed 88 pediatric patients (median age 7.3 years) who had B-lineage acute lymphoblastic leukemia (B-ALL), using reverse transcriptase-polymerase chain reaction, to look for gene fusion transcripts of TEL/AML1, E2A… CONTINUE READING


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