Molecular and cellular physiology of aromatase in the brain and retina.

@article{Callard1993MolecularAC,
  title={Molecular and cellular physiology of aromatase in the brain and retina.},
  author={Gloria V. Callard and M E Drygas and Danielle Gelinas},
  journal={The Journal of steroid biochemistry and molecular biology},
  year={1993},
  volume={44 4-6},
  pages={541-7}
}
Due to exceptionally high brain aromatase activity, teleost fish are advantageous for studying neural aromatase regulation, localization, and physiology. To determine the molecular mechanism of enhanced expression, we have isolated, cloned and sequenced a 3 kb full-length aromatase cDNA from a goldfish (Carassius auratus) brain library using a human placental aromatase cDNA as probe. The deduced sequence of goldfish aromatase is 510 amino acids (predicted Mw, 58 kDa) with 69% overall sequence… CONTINUE READING