Molecular and cellular mechanisms of pulmonary fibrosis

  title={Molecular and cellular mechanisms of pulmonary fibrosis},
  author={Nevins W. Todd and Irina G. Luzina and Sergei P. Atamas},
  booktitle={Fibrogenesis & tissue repair},
Pulmonary fibrosis is a chronic lung disease characterized by excessive accumulation of extracellular matrix (ECM) and remodeling of the lung architecture. Idiopathic pulmonary fibrosis is considered the most common and severe form of the disease, with a median survival of approximately three years and no proven effective therapy. Despite the fact that effective treatments are absent and the precise mechanisms that drive fibrosis in most patients remain incompletely understood, an extensive… CONTINUE READING

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