Molecular and cellular mechanisms of neuronal cell death in HIV dementia

  title={Molecular and cellular mechanisms of neuronal cell death in HIV dementia},
  author={Wenxue Li and David Galey and Mark P. Mattson and Avindra Nath},
  journal={Neurotoxicity Research},
The deaths of neurons, astrocytes and endothelial cells have been described in patients with HIV (human immunodeficiency virus) dementia. HIV-1 does not infect neurons; instead, neurotoxic substances shed by infected glia and macrophages can induce a form of programmed cell death called apoptosis in neurons. These neurotoxins include the HIV-1 proteins Tat and gp120, as well as proinflammatory cytokines, chemokines, excitotoxins and proteases. In this article we review the evidence for… CONTINUE READING
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The neuropathology of adult HIV infection

  • JE Bell
  • Rev. Neurol. (Paris)
  • 1998
Highly Influential
11 Excerpts

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