Molecular and cellular mechanisms of mammalian cell fusion.

  title={Molecular and cellular mechanisms of mammalian cell fusion.},
  author={Xiaofeng Zhou and Jeffrey L Platt},
  journal={Advances in experimental medicine and biology},
The fusion of one cell with another occurs in development, injury and disease. Despite the diversity of fusion events, five steps in sequence appear common. These steps include programming fusion-competent status, chemotaxis, membrane adhesion, membrane fusion, and post-fusion resetting. Recent advances in the field start to reveal the molecules involved in each step. This review focuses on some key molecules and cellular events of cell fusion in mammals. Increasing evidence demonstrates that… CONTINUE READING