Molecular and cellular mechanisms of pharmacoresistance in epilepsy.

@article{Remy2006MolecularAC,
  title={Molecular and cellular mechanisms of pharmacoresistance in epilepsy.},
  author={Stefan Remy and Heinz Beck},
  journal={Brain : a journal of neurology},
  year={2006},
  volume={129 Pt 1},
  pages={
          18-35
        }
}
Epilepsy is a common and devastating neurological disorder. In many patients with epilepsy, seizures are well-controlled with currently available anti-epileptic drugs (AEDs), but a substantial (approximately 30%) proportion of patients continue to have seizures despite carefully optimized drug treatment. Two concepts have been put forward to explain the development of pharmacoresistance. The transporter hypothesis contends that the expression or function of multidrug transporters in the brain… CONTINUE READING

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