Molecular and cellular mechanisms of altered GAD1/GAD67 expression in schizophrenia and related disorders

  title={Molecular and cellular mechanisms of altered GAD1/GAD67 expression in schizophrenia and related disorders},
  author={S. Akbarian and Hsien-Sung Huang},
  journal={Brain Research Reviews},
  • S. Akbarian, Hsien-Sung Huang
  • Published 2006
  • Biology, Medicine
  • Brain Research Reviews
  • The 67 and 65 kDa isoforms of glutamic acid decarboxylase, the key enzymes for GABA biosynthesis, are expressed at altered levels in postmortem brain of subjects diagnosed with schizophrenia and related disorders, including autism and bipolar illness. The predominant finding is a decrease in GAD67 mRNA levels, affecting multiple brain regions, including prefrontal and temporal cortex. Postmortem studies, in conjunction with animal models, identified several mechanisms that contribute to the… CONTINUE READING
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