Molecular and cellular mechanisms of altered GAD1/GAD67 expression in schizophrenia and related disorders
@article{Akbarian2006MolecularAC, title={Molecular and cellular mechanisms of altered GAD1/GAD67 expression in schizophrenia and related disorders}, author={S. Akbarian and Hsien-Sung Huang}, journal={Brain Research Reviews}, year={2006}, volume={52}, pages={293-304} }
The 67 and 65 kDa isoforms of glutamic acid decarboxylase, the key enzymes for GABA biosynthesis, are expressed at altered levels in postmortem brain of subjects diagnosed with schizophrenia and related disorders, including autism and bipolar illness. The predominant finding is a decrease in GAD67 mRNA levels, affecting multiple brain regions, including prefrontal and temporal cortex. Postmortem studies, in conjunction with animal models, identified several mechanisms that contribute to the… CONTINUE READING
Topics from this paper
319 Citations
GAD2 Alternative Transcripts in the Human Prefrontal Cortex, and in Schizophrenia and Affective Disorders
- Biology, Medicine
- PloS one
- 2016
- 15
- PDF
Transcriptional regulation of GAD1 GABA synthesis gene in the prefrontal cortex of subjects with schizophrenia
- Biology, Medicine
- Schizophrenia Research
- 2015
- 40
The Dynamics of DNA Methylation in Schizophrenia and Related Psychiatric Disorders
- Biology, Medicine
- Neuropsychopharmacology
- 2013
- 200
- PDF
Altered expression of genes involved in GABAergic transmission and neuromodulation of granule cell activity in the cerebellum of schizophrenia patients.
- Biology, Medicine
- The American journal of psychiatry
- 2008
- 81
- PDF
Decreased glutamic acid decarboxylase(67) mRNA expression in multiple brain areas of patients with schizophrenia and mood disorders.
- Psychology, Medicine
- Journal of psychiatric research
- 2009
- 131
- Highly Influenced
GAD1 mRNA Expression and DNA Methylation in Prefrontal Cortex of Subjects with Schizophrenia
- Biology, Medicine
- PloS one
- 2007
- 198
- PDF
Cortical Glutamic Acid Decarboxylase 67 Expression in Schizophrenia: Defining the Deficit
- Psychology
- 2011
- Highly Influenced
- PDF
Genetic Modulation of GABA Levels in the Anterior Cingulate Cortex by GAD1 and COMT
- Biology, Medicine
- Neuropsychopharmacology
- 2010
- 63
References
SHOWING 1-10 OF 129 REFERENCES
GAD67 and GAD65 mRNA and protein expression in cerebrocortical regions of elderly patients with schizophrenia
- Biology, Medicine
- Journal of neuroscience research
- 2004
- 94
GABAergic dysfunction in schizophrenia and mood disorders as reflected by decreased levels of glutamic acid decarboxylase 65 and 67 kDa and Reelin proteins in cerebellum
- Psychology, Medicine
- Schizophrenia Research
- 2005
- 240
GAD1 (2q31.1), which encodes glutamic acid decarboxylase (GAD67), is associated with childhood-onset schizophrenia and cortical gray matter volume loss
- Biology, Medicine
- Molecular Psychiatry
- 2005
- 195
- PDF
Polymorphisms in glutamate decarboxylase genes: analysis in schizophrenia
- Biology, Medicine
- Psychiatric genetics
- 2004
- 23
Decrease in reelin and glutamic acid decarboxylase67 (GAD67) expression in schizophrenia and bipolar disorder: a postmortem brain study.
- Psychology, Medicine
- Archives of general psychiatry
- 2000
- 1,044
- PDF
Relationship of Brain-Derived Neurotrophic Factor and Its Receptor TrkB to Altered Inhibitory Prefrontal Circuitry in Schizophrenia
- Psychology, Medicine
- The Journal of Neuroscience
- 2005
- 323
- PDF
GAD67: the link between the GABA-deficit hypothesis and the dopaminergic- and glutamatergic theories of psychosis
- Medicine
- Journal of Neural Transmission
- 2003
- 50
An association study between polymorphisms in five genes in glutamate and GABA pathway and paranoid schizophrenia.
- Biology, Medicine
- European psychiatry : the journal of the Association of European Psychiatrists
- 2005
- 22
An epigenetic mouse model for molecular and behavioral neuropathologies related to schizophrenia vulnerability
- Biology, Medicine
- Proceedings of the National Academy of Sciences of the United States of America
- 2002
- 364
- PDF
Differential hippocampal expression of glutamic acid decarboxylase 65 and 67 messenger RNA in bipolar disorder and schizophrenia.
- Psychology, Medicine
- Archives of general psychiatry
- 2002
- 258
- PDF