Molecular and cellular mechanisms of altered GAD1/GAD67 expression in schizophrenia and related disorders
@article{Akbarian2006MolecularAC, title={Molecular and cellular mechanisms of altered GAD1/GAD67 expression in schizophrenia and related disorders}, author={Schahram Akbarian and Hsien-Sung Huang}, journal={Brain Research Reviews}, year={2006}, volume={52}, pages={293-304} }
339 Citations
GAD2 Alternative Transcripts in the Human Prefrontal Cortex, and in Schizophrenia and Affective Disorders
- Psychology, MedicinePloS one
- 2016
Alternative transcripts of GAD2 may be important in the growth and development of GABA-synthesizing neurons as well as abnormal GABA signaling in the DLPFC of patients with schizophrenia and affective disorders.
Transcriptional regulation of GAD1 GABA synthesis gene in the prefrontal cortex of subjects with schizophrenia
- Psychology, BiologySchizophrenia Research
- 2015
GAD1 Gene Expression in Blood of Patients with First-Episode Psychosis
- Medicine, PsychologyPloS one
- 2017
Further correlation and validation work between brain regions, cerebrospinal fluid and peripheral blood expression profiling are required to provide a better understanding of GAD25 and GAD67.
The Dynamics of DNA Methylation in Schizophrenia and Related Psychiatric Disorders
- Psychology, BiologyNeuropsychopharmacology
- 2013
Understanding of altered CpG methylation, hydroxymethylation, and active DNA demethylation provide a framework for the identification of new targets, which may be exploited for the pharmacological intervention of the psychosis associated with SZ and possibly BP+.
Altered expression of genes involved in GABAergic transmission and neuromodulation of granule cell activity in the cerebellum of schizophrenia patients.
- Psychology, BiologyThe American journal of psychiatry
- 2008
The findings suggest that GABA transmission is decreased in the cerebellar cortices in individuals with schizophrenia and additional gene expression changes may reflect an attempt to increase GABA neurotransmission at the Cerebellar glomerulus.
The Impact of Oxidative Stress on GAD67 Levels and Parvalbumin-Positive Neurons
- Psychology, Biology
- 2015
A large preclinical and cognitive literature suggests that a dysfunctional frontal GABAergic network is associated to abnormal electroencephalographic spectra, which are thought to underlie higher cognitive functions and are known to be disturbed in schizophrenia.
Decreased glutamic acid decarboxylase(67) mRNA expression in multiple brain areas of patients with schizophrenia and mood disorders.
- Psychology, MedicineJournal of psychiatric research
- 2009
GAD1 mRNA Expression and DNA Methylation in Prefrontal Cortex of Subjects with Schizophrenia
- Biology, PsychologyPloS one
- 2007
Results suggest that chromatin remodeling mechanisms are involved in dysregulated GABAergic gene expression in schizophrenia, with a significant, on average 8-fold deficit in repressive chromatin-associated DNA methylation at the promoter.
Cortical Glutamic Acid Decarboxylase 67 Expression in Schizophrenia: Defining the Deficit
- Psychology, Biology
- 2011
An extensive characterization of the GAD67 deficit in schizophrenia is provided, and novel evidence of a functional impairment in PV neurons that may underlie cognitive deficits is provided.
Genetic Modulation of GABA Levels in the Anterior Cingulate Cortex by GAD1 and COMT
- Psychology, BiologyNeuropsychopharmacology
- 2010
The results support the importance of genetic variation in GAD1 and COMT in regulating prefrontal cortical GABA function, and the directionality of the effects is inconsistent with earlier evidence of decreased GABA activity in schizophrenia.
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GAD1 (2q31.1), which encodes glutamic acid decarboxylase (GAD67), is associated with childhood-onset schizophrenia and cortical gray matter volume loss
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