Molecular and cellular mechanism of angiotensin II-mediated apoptosis.

  title={Molecular and cellular mechanism of angiotensin II-mediated apoptosis.},
  author={Masatsugu Horiuchi and Masahiro Akishita and V J Dzau},
  journal={Endocrine research},
  volume={24 3-4},
It is well known that angiotensin II exerts growth promoting effects via the angiotensin II type 1 (AT1) receptor. We have cloned a second type of angiotensin II receptor (AT2 receptor) and demonstrated that this receptor acts as an antagonistic receptor against the AT1 receptor. Moreover, we have demonstrated that the AT2 receptor exerts growth inhibitory and proapoptotic effects by antagonizing the effects of the AT1 receptor and growth factors in several cell lines including vascular smooth… CONTINUE READING


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