Molecular and cellular function of the proprotein convertase subtilisin/kexin type 9 (PCSK9)

@inproceedings{Schulz2015MolecularAC,
  title={Molecular and cellular function of the proprotein convertase subtilisin/kexin type 9 (PCSK9)},
  author={Rainer Schulz and Klaus-Dieter Schl{\"u}ter and Ulrich Laufs},
  booktitle={Basic Research in Cardiology},
  year={2015}
}
The proprotein convertase subtilisin/kexin type 9 (PCSK9) has emerged as a promising treatment target to lower serum cholesterol, a major risk factor of cardiovascular diseases. Gain-of-function mutations of PCSK9 are associated with hypercholesterolemia and increased risk of cardiovascular events. Conversely, loss-of-function mutations cause low-plasma LDL… CONTINUE READING