Molecular and cellular determinants for generating ES-cell derived dopamine neurons for cell therapy.

Abstract

Embryonic stem (ES) cells can generate midbrain dopaminergic (DA) neuronal phenotypes in vitro and have been successfully applied to restore function in animal models of Parkinson's disease (PD). How can we best integrate our growinginsight into the regulatory cascade of transcription factors guiding midbrain specification to further improve the in vitro… (More)

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Cite this paper

@article{Pruszak2009MolecularAC, title={Molecular and cellular determinants for generating ES-cell derived dopamine neurons for cell therapy.}, author={Jan Pruszak and O. Isacson}, journal={Advances in experimental medicine and biology}, year={2009}, volume={651}, pages={112-23} }