Molecular and cellular biology of small cell lung cancer.

  title={Molecular and cellular biology of small cell lung cancer.},
  author={Martin Sattler and Ravi Salgia},
  journal={Seminars in oncology},
  volume={30 1},
For any tumor to become cancerous, various genetic mutations and biologic alterations must occur in the cell that in combination render it a malignant neoplasm. Small cell lung cancer (SCLC) is a neoplasm associated with several molecular and cellular abnormalities. SCLC is associated with early and frequent metastasis as well as a poor ultimate response to chemotherapy. New and novel therapies based on understanding the mechanisms of transformation are needed. SCLC is associated with multiple… CONTINUE READING