Molecular and cellular biology of osteopontin Potential role in cardiovascular disease.

@article{Giachelli1995MolecularAC,
  title={Molecular and cellular biology of osteopontin Potential role in cardiovascular disease.},
  author={Cecilia M. Giachelli and Stephen M Schwartz and Lucy Liaw},
  journal={Trends in cardiovascular medicine},
  year={1995},
  volume={5 3},
  pages={
          88-95
        }
}
Molecular biology has greatly enhanced our ability to identify molecules expressed as a part of the vascular response to injury. Among these, osteopontin is of particular interest. Osteopontin is a multifunctional adhesive glycoprotein implicated in the pathogenesis of a growing number of cardiovascular lesions, including restenosis, atherosclerosis, aortic valve calcification, and repair of myocardial wounds. In this review, we focus on structural, functional, and regulatory properties of… CONTINUE READING
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