Molecular and cellular basis of epileptogenesis in symptomatic epilepsy.

@article{Pitknen2009MolecularAC,
  title={Molecular and cellular basis of epileptogenesis in symptomatic epilepsy.},
  author={Asla Pitk{\"a}nen and Katarzyna Lukasiuk},
  journal={Epilepsy & behavior : E&B},
  year={2009},
  volume={14 Suppl 1},
  pages={16-25}
}
Epileptogenesis refers to a process in which an initial brain-damaging insult triggers a cascade of molecular and cellular changes that eventually lead to the occurrence of spontaneous seizures. Cellular alterations include neurodegeneration, neurogenesis, axonal sprouting, axonal injury, dendritic remodeling, gliosis, invasion of inflammatory cells, angiogenesis, alterations in extracellular matrix, and acquired channelopathies. Large-scale molecular profiling of epileptogenic tissue has… CONTINUE READING
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