Molecular and cellular analysis of basement membrane invasion by human breast cancer cells in Matrigel-based in vitro assays.

@article{Bae1993MolecularAC,
  title={Molecular and cellular analysis of basement membrane invasion by human breast cancer cells in Matrigel-based in vitro assays.},
  author={S N Bae and Gloria Arand and H. Azzam and Prasit Pavasant and Jeff Torri and Thomas Leth Frandsen and Erik W Thompson},
  journal={Breast cancer research and treatment},
  year={1993},
  volume={24 3},
  pages={241-55}
}
In vitro analyses of basement membrane invasiveness employing Matrigel (a murine tumor extract rich in basement membrane components) have been performed on human breast cancer model systems. Constitutive invasiveness of different human breast cancer (HBC) cell lines has been examined as well as regulation by steroid hormones, growth factors, and oncogenes. Carcinoma cells exhibiting a mesenchymal-like phenotype (vimentin expression, lack of cell border associated uvomorulin) show dramatically… CONTINUE READING

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