Molecular and cell signaling targets for PTSD pathophysiology and pharmacotherapy

@article{Hauger2012MolecularAC,
  title={Molecular and cell signaling targets for PTSD pathophysiology and pharmacotherapy},
  author={Richard L. Hauger and Jes{\'u}s Alberto Olivares-Reyes and Frank Matthias Dautzenberg and James B. Lohr and Robert H Oakley},
  journal={Neuropharmacology},
  year={2012},
  volume={62},
  pages={705-714}
}
The reasons for differences in vulnerability or resilience to the development of posttraumatic stress disorder (PTSD) are unclear. Here we review key genetic diatheses and molecular targets especially signaling pathways that mediate responses to trauma and severe stress and their potential contribution to the etiology of PTSD. Sensitization of glucocorticoid receptor (GR) signaling and dysregulation of GR modulators FKBP5, STAT5B, Bcl-2, and Bax have been implicated in PTSD pathophysiology… CONTINUE READING

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